Rosh Internal Medicine Boost End of Rotation (EOR) Practice Exam

In cases of iron deficiency anemia, one of the hallmark laboratory findings is microcytic anemia, which is characterized by smaller than normal red blood cells. This condition occurs due to insufficient iron, which is essential for hemoglobin synthesis. When the body lacks iron, hemoglobin production is impaired, leading to the production of these smaller red blood cells.

Additionally, low serum ferritin levels are indicative of depleted iron stores in the body. Ferritin is a protein that stores iron, and low levels suggest that the body’s iron reserves are insufficient to meet its needs. Thus, when a patient is diagnosed with iron deficiency anemia, the combination of microcytic anemia and low serum ferritin effectively supports the diagnosis, as it reflects the underlying pathophysiology of insufficient iron supply necessary for red blood cell formation.

This laboratory finding is crucial for differentiating iron deficiency anemia from other types of anemia, such as those caused by vitamin B12 or folate deficiency, which typically present with macrocytic anemia instead.