What is the first step in the management of anaphylaxis?

The first step in the management of anaphylaxis is the administration of epinephrine. Anaphylaxis is a severe, potentially life-threatening allergic reaction that requires immediate treatment to reverse the symptoms. Epinephrine acts quickly to constrict blood vessels, increase blood pressure, and improve airway swelling and breathing.

When anaphylaxis occurs, the body releases a large amount of histamine and other mediators that can lead to symptoms such as difficulty breathing, swelling of the throat, and a drop in blood pressure. Administering epinephrine rapidly counteracts these effects, making it the priority in an acute setting.

While calling for emergency services is essential due to the potential for severe complications and the need for additional care, it is important to initiate treatment immediately. Delaying the administration of epinephrine while waiting for emergency responders can result in significant morbidity and mortality. Antihistamines and glucocorticoids are useful in the treatment of allergic reactions but are not effective in reversing the acute symptoms of anaphylaxis and should be administered after epinephrine when appropriate.