What is the most appropriate therapy for a patient with peripheral vascular disease and intermittent calf pain?

The most appropriate therapy for a patient with peripheral vascular disease (PVD) and intermittent calf pain is a comprehensive approach that includes aspirin, cilostazol, rosuvastatin, smoking cessation, and structured exercise.

Aspirin is commonly used for its antiplatelet effects, which help reduce the risk of cardiovascular events in patients with PVD. Cilostazol is specifically indicated for claudication related to PVD, as it improves symptoms of intermittent claudication by increasing blood flow to the muscles during exercise. Rosuvastatin is a statin used to manage cholesterol levels, which is crucial in patients with PVD to reduce cardiovascular risk. Smoking cessation is vital because smoking exacerbates vascular disease and improves outcomes when patients stop smoking. Structured exercise programs have been shown to improve functional status and alleviate symptoms of claudication, promoting better mobility and quality of life.

Together, these components form a multi-faceted management strategy that addresses the patients' symptoms, improves their overall cardiovascular health, and decreases the risk of disease progression. This integrated approach is aligned with current guidelines for managing peripheral vascular disease and optimizing patient outcomes.