Which medication is likely the best choice for improving pain in a patient with fibromyalgia?

Amitriptyline is considered one of the most effective medications for managing pain in patients with fibromyalgia. This tricyclic antidepressant has been shown to help improve sleep quality, reduce pain perception, and alleviate the fatigue often associated with fibromyalgia. Its analgesic properties are believed to be related to its effects on neurotransmitters in the central nervous system, including serotonin and norepinephrine, which can play a crucial role in modulating pain pathways.

In fibromyalgia treatment, the goal is often to manage not just the pain, but also related symptoms such as sleep disturbances and mood disorders. Amitriptyline addresses these multiple facets, making it a comprehensive treatment option for individuals suffering from this condition. The favorable outcomes in pain relief and overall improvement in quality of life underscore its preference as a first-line therapeutic choice for fibromyalgia.